Year 2000 (MM) was a leap year of the Gregorian calendar that started on a Saturday.
- January 17 - Sleepy Time and Suds premiered.
- February 14 - Valentine's Day and The Paper premiered.
- March 15 -Arrgh! and Rocket Bottom premiered.
- March 22 - Texas and Walking Small premiered.
- April 1 - Fools in April and Neptune's Spatula premiered.
- April 8 - Mermaid Man and Barnacle Boy 2 premiered.
- October 26 - Something Smells and Bossy Boots premiered.
- November 2 - Your Shoe's Untied and Squid's Day Off premiered.
- November 16 - Big Pink Loser and Bubble Buddy premiered.
- November 27 - Mermaid Man and Barnacle Boy 3 and Squirrel Jokes premiered.
- December 6 - Christmas Who? premiered.
- December 28 - Dying for Pie and Imitation Krabs premiered.