While he was looking for spare change as usual in his cheap ways, Mr. Krabs noticed an over-sized soy bean near Sandy's treedome. Interested in what could have enlarged the plant, he asked Sandy a tour of her residence. Sandy revealed the growth serum that made the plant enlarged, prompting Mr. Krabs to use it in a Krabby Patty. Using Sandy's phone, he called SpongeBob for a Krabby Patty to test the growth serum. Sandy agrees to use the serum on the Krabby Patty, but only one drop. The experiment, to Krabs' satisfaction, works. Sandy abruptly excuses herself to use the toilet, leaving the serum with Krabs. He promptly pours every drop on the patty, guaranteeing another money-making scheme. However, the patty keeps growing. Havoc ensues.
Mr. Krabs, still thinking it would make him rich, tried to keep SpongeBob and Squidward at the Krusty Krab to work until Mr. Krabs sees the cash register getting buried by it. He then runs to save it but is then swallowed up as well. SpongeBob and Squidward then ran away as the Krabby Patty devours the whole Krusty Krab completely. In the Chum Bucket, Plankton sees it, and thinking that it was the biggest Krabby Patty that he has ever seen, he runs to it. SpongeBob tries to warn him that he has to get away from the patty, but he never listens, getting swallowed up as well. Now expanding to a colossal scale, it began consuming Bikini Bottom.
SpongeBob runs, hoping to find a solution at Sandy's house, finds her treedome destroyed. Sandy calls to him from her helicopter, and she reveals that the only way to reverse the extending process was if SpongeBob got direct contact with the big patty. SpongeBob complied and absorbed the giant mass of meat into his absorbent body. Everything was back to normal except for SpongeBob in Krabby Patty form and huge. The Krabby Patties which were absorbed were added as Pre-Absorbed Patties in the Krusty Krab. The episode ends with Mr. Krabs selling rare absorbed Krabby Patties at the Krusty Krab while SpongeBob makes it with his thumb from the Krabby Patty, because he was elongated with absorbed meat.
Mr. Krabs magnet was a failed scheme, as money is non-magnetic.
However, SpongeBob's fridge magnet, swallowed by Gary, attracted coins in "The Cent of Money."
When Mr. Krabs is using a magnet to search for money and attracts the other magnet, the sand only covers the other magnet itself. When the sand washes away, a rope can be seen attached to that magnet.
Mr. Krabs didn't need a water helmet, since he is a crab. Crabs can breathe both air and water, but this questions as to why Mr. Krabs wore a water helmet in "Overbooked."
When Squidward mentioned that SpongeBob comes to work half barefoot, it may or may not be a reference to SpongeBob sleeping barefoot at work in "New Digs."
Plankton could have easily taken a piece of the giant Krabby Patty and run back to The Chum Bucket without getting caught.
Especially since everyone was focused on the giant Krabby Patty.
Nat appears as a Policeman in this episode.
In this episode, a cop is seen writing a parking ticket, until the Giant Krabby Patty swallows the car and belches out the motor, which the cop puts the ticket on. A similar joke was used in a earlier episode called "Sandy, SpongeBob, and the Worm."
This is the second time Mr. Krabs entered Sandy's Treedome. The first time was in "Overbooked."
This episode is a parody of the 1958 movie The Blob and its 1988 remake.
This episode could also be a parody of the Goosebumps book that is also another parody of The Blob called "The Blob That Ate Everyone," except the plot is a little different.
The title of this episode is possibly a spoof of the title of an already parody 1999 song called "The Pizza That Ate Chicago" by Tom Paxton.
In Sandy's Treedome, bubbles appeared during motion like it was underwater, even though the Treedome is dry. There were two such occasions: one was when Mr. Krabs put the phone down and the other is when he picked it up.
Sandy should've gotten angry at Mr. Krabs for using a whole lot of the serum, which caused the giant patty in the first place.
When SpongeBob makes Krabby Patties from the giant patty, they do not grow along with the giant Krabby Patty, even though they have growth serum on them.
In the kitchen, the Krabby Patty eats SpongeBob's left shoe and sock. When SpongeBob and Squidward try to exit the restaurant, it reappears for no apparent reason and remains like that for the rest of the episode.