SpongeBob begins singing while cooking the patties. An annoyed Squidward tells him about real music and plays his clarinet, causing the customers to run out of the Krusty Krab. After being told to stop by Mr. Krabs, Squidward goes outside and throws a tantrum, complaining that no one appreciates music. Plankton, watching from the Chum Bucket, believes that Squidward may be the key to the formula.
Later, Plankton tries talking to Squidward, but he fails to. Then, he makes several attempts to trick Squidward, among these were pretending to be a girl scout and pretending to be one of Squidward's species, all resulting in Plankton getting the door literally slammed in his face. SpongeBob tells Plankton that he might gain Squidward's friendship if he compliments him on his music. Plankton later meets with Squidward and persuades him to play his clarinet. At first, Plankton is tormented by the awful clarinet music, but then wears earplugs to block the noise and pretends to like the music. Squidward marches across Bikini Bottom playing his clarinet, and Plankton follows along, while everyone else is tormented by the noise. Plankton also sings a song about Squidward`s clarinet music as Squidward plays bad notes on his clarinet.
This friendship, however, wouldn't last as Plankton tells Squidward about the secret formula. Squidward tells Plankton that, despite 20 years of working, he has never saw the making of a Krabby Patty. Squidward tells Plankton that his music is getting better and plays his clarinet, making windows and mirrors across Bikini Bottom shatter. Squidward then says that he is going to quit his job and become a full-time musician. Plankton gets so angry, that his earplugs come off, and he is once again tortured by the noise. Plankton steals the clarinet, causing Squidward and SpongeBob to chase after him. Plankton is shortly confronted by the police about a "bad music" crime, and is arrested from being the only one to hold the clarinet. As he is driven away, the police car runs over Squidward's clarinet. After SpongeBob retrieves the broken clarinet, Squidward once again "hates people".
( ‣ ) Associated production music
( • ) Original music
( ◦ ) SpongeBob music
• ? - Sage Guyton, Jeremy Wakefield [title card] • ? - Michael Bolger, Nicolas Carr ["SpongeBob, what is that horrible racket?"] • ? - Nicolas Carr ["He must have been listening to hard rock."] ‣ ? ["I don't care!"] • ? - Nicolas Carr, Barry Anthony [Squidward playing clarinet] ‣Goofy Conversation - Nicolas Carr, Barry Anthony [Krabs takes Squidward's clarinet] ‣ ? [Plankton spying] • ? - Sage Guyton, Jeremy Wakefield [Squidward watering his garden] •Steel Link (e) - Jeremy Wakefield [Squidward pours water on Plankton] • ? - Sage Guyton, Jeremy Wakefield ["You again?"] ‣Steel Sting (b) - Jeremy Wakefield [Squidward pours water on Plankton again] ‣ ? [Squidward slamming the door on Plankton] ‣Fresh as a Daisy - George French [Plankton selling cookies] • ? - Nicolas Carr [Squidward slams the door] ‣Watch Out! - Dick Stephen Walter ["Plankton, what are you doing?"] ‣Cartoon Sting 9 - ? [Plankton pretending to be Squidward's long lost relative] ‣Steel Link (a) - Jeremy Wakefield ["That's a fine way to treat a family member."] • ? - Nicolas Carr ["Music?"] ‣ ? ["Oh, is that right?"] • ? - Pat Irwin [Plankton in Squidward's music book] • ? - Nicolas Carr, Barry Anthony [Squidward playing clarinet] ◦Neat Clarinet - Aaron Springer, Eban Schletter [Plankton sings this] • ? - Pat Irwin [Plankton asks what the secret formula is] ‣Dramatic Bridge 4 - Phillip Green [Plankton's earplugs fall out] • ? - Sage Guyton, Jeremy Wakefield [Squidward chases Plankton] ‣The Mob - Nicolas Carr, Barry Anthony [Plankton arrested] •Steel Link (i) - Jeremy Wakefield [ending]
Some cable providers list the episode as "Sweet and Sour Squidward".