SpongeBob wakes up in the morning, only to find out he has the suds. He tries to cover up the fact that he is ill so that he does not have to miss a day of work.
At the Krusty Krab, SpongeBob is sneezing on the food. Mr. Krabs finds out that he is sick, so he orders SpongeBob to go home and get some rest. At SpongeBob's house, SpongeBob's suds have gotten worse, so he calls Sandy to take him to the doctor.
While SpongeBob is waiting for Sandy, Patrick comes by and asks if he is going skiing. SpongeBob tells him that he has the suds, and that he is going to the doctor. However, Patrick tells him all the bad things about doing so. SpongeBob is scared of the doctor now and begs Patrick to look after him instead. Patrick agrees.
Patrick is seen trying to cure SpongeBob by putting corks in his holes, making SpongeBob get bigger and fatter every time he sneezed. SpongeBob thinks he is better, so he goes to call Sandy and tells her not to come. However, his fingers are too big for the buttons, so he asks Patrick to call her. Patrick does this. Sandy is seen in her treedome working out and Patrick tells her everything. Sandy then says she'll go and have a look at SpongeBob. Patrick goes into a panic and tells SpongeBob that Sandy will take him to the doctor.
After some time, Sandy comes and finds out that SpongeBob is not cured and she and Patrick have a war over SpongeBob's health. The latter (thanks to Sandy and Patrick) goes flying into the air and lands near the Krusty Krab. He gives a big sneeze and the building blows up.
SpongeBob is back to his normal size and Sandy takes him to a real doctor. The doctor gives SpongeBob some medicine and he is better in no time.
SpongeBob is sitting in bed with a thermometer in his mouth. He has a red nose with blushing cheeks, is holding a dark green blanket, and there's a lot of tissues on his bed.
In the ending of the book, the doctor gives SpongeBob medicine, while in the episode this book is based on, he receives the sponge treatment. Also, Patrick is forced to read old magazines, while in the episode, he gets a starfish treatment.
In the beginning of the book, SpongeBob wakes up out of bed, sick, while in the episode, he wakes up freezing in the kitchen, sick.
SpongeBob is seen with a bunch of tissues of cover, despite him not using any tissues when he actually got the suds.