SpongeBob and Patrick get new slide whistles and keep playing them, much to the annoyance of Squidward. He becomes increasingly annoyed as they use the slide whistles as sound effects for everything he does. He eventually has enough of it and flees his house. SpongeBob and Patrick follow him, thinking he is finally playing with them and ignoring his cries to leave him alone. He snaps and grabs SpongeBob's slide whistle and uses it on them. SpongeBob says he has an equally better ear for music and soon buys one himself. Squidward then plays it around town: first, he scares Dennis out of his wits as Dennis thinks he is being annoyed by ghosts and Squidward impersonates a baby and scares Sadie out of her wits, making her see Squidward as a "baby assaulter," resulting in the annoyance of a lot of people.
Soon, they form an angry mob and end on the warpath against Squidward. Squidward manages to take control over a gasoline tanker truck, destroys the Chum Bucket and the Krusty Krab, jumps over a row of boats through a ring of fire, and drives away from the mob. Squidward says he does not want to stop but then SpongeBob and Patrick (driving a boat) ask if he is sure he does not want to stop. Then Squidward sees that SpongeBob was trying to warn him that a cliff was ahead but there is nothing Squidward can do about it now. SpongeBob and Patrick stop just in time but the gasoline tanker truck keeps going and falls off the cliff, causing it to explode, much to the joy of the town as they see that Squidward is finally stopped. At the hospital, the whistle gets stuck in his throat and since they do not have the technology to remove it, they just left it there. SpongeBob and Patrick then play around the hospital with the whistles.
This episode is number 6 on Tom Kenny's Top 20 on iTunes. His description says:
"SpongeBob and Patrick drive Squidward nuts with their new slide whistles. I'm a sucker for any episode where a tiny thing gets on Squidward's nerves until he snaps. (Roger [sic] Bumpass is great at vocalizing Squidward’s 'losing it.')"
As of August 14, 2016, The Internet Movie Database (IMDB) gives this episode a rating of 4.7/10 based on 197 ratings by users. TV.com users give this episode a 4.9/10 based on 178 votes.
When the police officer is attacked by the worms, he says "I'm supposed to retire this week!" This is a reference to the captain of the Titanic, Edward J. Smith, when he died on the voyage before he was supposed to retire.
The scene with Squidward in the truck falling off the hill and people cheering is a reference to the 1971 movie Duel where the truck driver falls off the hill and the protagonist starts cheering.
The sound of the slide whistles follow the background music at some points.
When Squidward falls off the cliff, in an explosion, SpongeBob and Patrick play the funeral march on their slide-whistles.
At the beginning of the episode when Squidward is bathing, the water is black then turns blue.
When Squidward finds SpongeBob and Patrick under the mat, SpongeBob’s socks are gone.
When SpongeBob and Patrick are explaining Slide Whistles to Squidward near the episode's beginning, Patrick looks (very slightly) off.
When SpongeBob and Patrick jump into the paintings, when they fly out, one of the paintings of Squidward's eyes change colors.
When Squidward was using his slide whistle around town, the people were annoyed by his antics, even forming an Angry Mob. However, when SpongeBob and Patrick use their slide whistles in the hospital, everyone thinks it is funny.
The driver of the truck spits his coffee near an air vent. Later, the coffee and the vent are gone when Squidward drives it.
When Squidward gets in the driver's seat of the truck and takes the wheel, the wheel goes the opposite way he is turning it.
When Squidward drives through the Krusty Krab, the kitchen, bathrooms, freezer, and Mr. Krabs's office cannot be seen.
When Squidward is first driving the truck, his feet are on the wheel, but his hands are on the slide whistle, so the truck shouldn't be moving.
When SpongeBob and Patrick drive the boat to the cliff, after the explosion, the scene changes and the boat is gone.
The Purple Doctorfish says that they do not have the "technology" to remove the slide whistle from Squidward's throat while the whistle is only hanging from his throat by the tip.
Sadie first appears in orange in this episode but is yellow in later scenes.
Mr. Krabs was never credited even though he actually had lines.