- Karen Plankton
- Sheldon J. Plankton
- Squidward Tentacles
- SpongeBob SquarePants
- Clay (cameo)
- Nat Peterson (cameo)
- Norma Rechid (cameo)
- Sandy Cheeks (cameo)
- Butterflies (mentioned)
- Patrick Star
- Amoeba (text)
- Harold "Bill" Reginald
- Nancy Suzy Fish
- Shelly Fishbowl
- Taylor Fishbowl
- E.M.I.L.P. (debut)
- ATM (mentioned)
SynopsisPlankton walks to the Chum Bucket stinking with the stench of "Failure" as he calls it, and Karen is in a very happy mood. Karen then smells Plankton and gives him a bath, taking off his skin, which is revealed to be his clothes. After he's washed, Plankton learns that it was his and Karen's wedding anniversary and that Karen got him a copy of the Krabby Patty secret formula for his present, but he can't have it until he gets her a present.
Plankton is crying on the road and SpongeBob hears the crying sound. He sniffs like a dog and soon runs into Plankton. He tells SpongeBob the news and SpongeBob yells to all of Bikini Bottom that there's a "Love Emergency." SpongeBob then tells Plankton that his present has to come from the heart, and he suggests a serenade. Plankton then remarks that he cannot sing, and SpongeBob takes him to the pineapple and works on Plankton's vocal cords. Plankton sings so high that he breaks the glass Squidward was drinking out of his juice and Sandy's helmet breaks while she was walking then she runs back to her treedome for air. Then, Plankton goes off to serenade Karen.
Plankton walks into the Chum Bucket and starts singing a mariachi-style song, and SpongeBob and Patrick play guitars in the background, wearing Mexican-style clothing and mustaches. Plankton also shakes maracas. Karen cries when it is over, and then she starts uploading the Krabby Patty secret formula. SpongeBob is mad at this, so he unplugs what he thinks is Karen, but was just the coffee maker. Karen finally uploads the formula, but she starts crying again, and she breaks down and shorts out, leaving Plankton still without the secret formula, making Plankton confused. She then shuts down, and the E.M.I.L.P (Emergency Mother-In-Law Program) uploads and starts nagging, saying that Karen could have married the ATM, someone with money.
|( ‣ ) Associated production music|
|( • ) Original music|
|( ◦ ) SpongeBob music|
‣ Wahini Wobble - Nicolas Carr, Sage Guyton, Jeremy Wakefield [title card]
‣ Emotion Blues - Francois Fournet, Eric Gemsa [Plankton comes home]
‣ Hawaiian Cocktail - Richard Myhill ["And now the smell of defeat so deeply penetrates my soul..."]
‣ Darting Around - Harry Bluestone [Karen cleaning Plankton]
‣ Steel Licks (d) - Jeremy Wakefield ["It's not enough to mask the ugliness I feel inside."]
‣ Darting Around - Harry Bluestone ["Did I miss a spot?"]
‣ Tension Bits - Nicolas Carr, Sage Guyton, Jeremy Wakefield [Plankton gets angry]
‣ Fantasy Princess [#52] - Harry Bluestone, Emil Cadkin ["It has something to do with you asking a certain someone..."]
‣ Vibe Sting - Nicolas Carr ["What?"]
‣ Bridal Chorus - Richard Wagner ["We each wear rings in memory of this moment."]
‣ Steel Sting - Jeremy Wakefield ["It's our wedding anniversary!"]
‣ Parting of the Clouds - Nicolas Carr [Karen got Plankton the secret formula]
‣ Botany Bay - Michael Bolger, Nicolas Carr [Karen explains how she got it through a flashback]
‣ ? - Nicolas Carr [Plankton kissing the formula bottle]
‣ Steel Sting (k) - Jeremy Wakefield [Karen wants a gift from Plankton]
‣ Hello Blues - Sage Guyton, Jeremy Wakefield ["And that's how I got my head stuck in the fry vat."]
‣ Accusation - Gerhard Trede [Plankton groaning]
‣ Vibe Sting - Nicolas Carr ["Plankton?"]
‣ Hawaiian Cocktail - Richard Myhill [Plankton tells SpongeBob about his wedding anniversary]
‣ Chasey Racey - Norman Dane [love emergency]
‣ Goofy Conversation - Nicolas Carr, Barry Anthony ["There's only one thing to do."]
‣ Sport Fanfare - Gerhard Trede ["That's it!"]
‣ Cartoon Sting 1 - Plankton telling SpongeBob about Karen
‣ Unknown Hawaiian Sting (l) - singing lessons
‣ Unknown Track 68 - Sandy's helmet breaks
‣ Climb to Altitude - Trevor Duncan ["Oh, you are ready!"]
‣ Tiki Rapido - Lionel Wendling ["This is it, Plankton."]
‣ Unknown Track 54 - Nicolas Carr ["Ah, love."]
‣ Lonely Heart's Club (a) - David Bell, Otto Sieben [Plankton returns home]
• Oh, My Karen - Luke Brookshier, Eban Schletter [Plankton sings]
‣ South Pacific Island II - Victor Cavini ["That was so beautiful!"]
‣ Crime & Danger Sign #3 - Hans Conzelmann, Delle Haensch ["The Krabby Patty formula?!"]
‣ Dramatic Sea Battle - Gerhard Trede ["I am so fired."]
‣ Victory of Love - Gerhard Trede [Karen crying]
‣ Steel Sting (b) - Jeremy Wakefield [computer shorts out]
‣ Skipping to School - Sage Guyton, Jeremy Wakefield [Emergency Mother-In-Law Program]
This episode is number 13 on Tom Kenny Top 20 on iTunes. His description says:
- "Kind of obscure, but one of the few episodes to focus on the 'honeymooners-like' marriage of Plankton and Karen (just a microorganism and his computer wife tryin' to get by). I love how Plankton swings between henpecked husband and world-conquering megalomaniac."
- This episode is available on the Triton's Revenge, Season 6 Volume 2, and Complete Sixth Season DVDs.
- This was the third episode to premiere during the Nickelodeon's "Deep Sea Danger Zone" marathon.
- Karen has a Boston accent while her "mother" has more of a New York/Jersey accent.
- Plankton's failures are usually his own fault or another character's. In this episode, it seems to be Karen's fault for crying and short circuiting. It may also briefly be Plankton's fault for forgetting their anniversary.
- Karen is upset with Plankton for not having an anniversary gift for her, but in the end, she is the one who fails to give the other an anniversary gift.
- SpongeBob was pressing the keys Ctrl, Alt, and Del. Karen is most likely based on a Windows system, since these keystrokes either allows the user to log on, opens a Task Manager or opens a screen with options like Task Manager on a real Windows computer.
- On the Nickelodeon schedule, this episode is called "Green Anniversary."
- SpongeBob knew what butterflies were in this episode, but not in "Wormy." Therefore, this episode must come after "Wormy."
- On the Complete Sixth Season and Season 6 Volume 2 DVDs, this was the final episode, but it was not the last episode that aired from Season 6 and it is not the last episode of this season in production order.
- This episode takes place before "Atlantis SquarePantis," The SpongeBob Movie: Sponge Out of Water, and Plankton's Holiday Hits because he sings in those.
- In "Enemy In-Law," Plankton says that he bought Karen. Yet in this episode, he says that he built her.
- This episode reveals that Karen is a Mark II Surplus UNIVAC with 256 gigabytes of RAM.
- This episode is one of the few episodes where Patrick appears, but has no lines.
- Karen's "ERROR" screen is a parody of blue screens usually found when a computer is malfunctioning.
- The title is a parody of either a single-celled organism or sickle-cell disease.
- At the beginning of the episode, Karen has the secret formula printed out in a bottle. However, at the end, Karen had to print it out.
- When SpongeBob attempts to Ctrl-Alt-Del Karen, the keyboard keys are white. When Karen begins to short circuit, they are red.