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Sandy and Plankton have had very few interactions around the series. Their first interaction was in "Someone's in the Kitchen with Sandy" when Plankton steals Sandy's fur in order to to trick Spongebob into giving him the Krabby Patty Formula this fails when Sandy comes in the Krusty Krab and tries to beat Plankton to get her fur back this fails and ends up sending her to jail. There second interaction was in "Perfect Chemistry" when Sandy and Plankton team up but what Sandy doesn't know was that Plankton was using her to get the Krabby Patty Formula but apparently sandy says she knew Plankton was going to trick him all along and sent Plankton to be trapped in Mr. Krabs' Krabby Patty Formula bottle after yet again failing his way to get the Krabby Patty Formula. They didn't interact much for two seasons until it came from goo lagoon where SpongeBob, Patrick and Sandy team up to defeat Plankton they soon find Mr. Krabs and Plankton being mean to one one another until Mr. Krabs yet again wins. Their latest interaction was in "Salsa Imbecilicus" where Sandy accidentally gives Plankton an evil plan to steal the recipe Plankton fails his plan and gets himself caught in Patrick's DNA making Sandy and Karen team up to help Plankton and the rest of Bikini Bottom.