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Sandy and Plankton have had very few interactions around the series. Their first interaction is in "Someone's in the Kitchen with Sandy" when Plankton steals Sandy's fur in order to trick SpongeBob into giving him the Krabby Patty Formula. This fails when Sandy comes into the Krusty Krab and tries to beat Plankton up to get her fur back, this also fails and ends up sending her to jail. Their second interaction is in "It Came From Goo Lagoon" when Sandy and Plankton team up, but what Sandy doesn't know is that Plankton was using her to get the Krabby Patty Formula. Sandy says she knew Plankton was going to trick her all along and sent Plankton to be trapped in Mr. Krabs' Krabby Patty Formula bottle after yet again failing his way to get the Krabby Patty Formula. They didn't interact much for two seasons until "Perfect Chemistry" where SpongeBob, Patrick, and Sandy team up to defeat Plankton. They soon find Mr. Krabs and Plankton being rude to one another until Mr. Krabs yet again wins. Their latest interaction is in "Salsa Imbecilicus" where Sandy accidentally gives Plankton an evil plan to steal the recipe. Plankton fails with his plan and gets himself caught in Patrick's DNA making. Sandy and Karen team up to help Plankton and the rest of Bikini Bottom. In "Mimic Madness" they are seen playing chess together and teamed up to get rid of SpongeBob's Mocking Mimicry Madness.