"Battle robotic clones to save the planet! Invader Zim has a sinister plot to overtake the earth in this action-pack-side-scroller, you'll do battle with SpongeBob, Danny Phantom or El Tigre. Harness their special powers and your math skills to battle the forces of evil!"
The game is a side-scrolling game similar to the GBASpongeBob games. The player takes control of SpongeBob, Danny Phantom, and El Tigre. As the Didj console is made to learn for children, the subject the game focuses on is math. There are times that the player will have to put the right number on the math problems to continue.
This was the only Nicktoons video game to ever be released on the Didj console.
Despite being able to canonically fit in the Nicktoons Unite! series, Android Invasion is not officially considered an installment of the specific series since it was made before Nicktoons: Attack of the Toybots made its debut and has no console counterpart.