Squidward has made a delicious soufflé, but SpongeBob and Patrick's constant laughing distracts him from enjoying it. Squidward sees that they are having a private conversation with bubbles. They whisper a message into the bubble wand instead of blowing into it, and when the bubble pops, the message can be heard.
Annoyed by that, Squidward makes bubbles of his own, imitating SpongeBob and Patrick, but insulting them both. Thinking the bubbles are from the other, SpongeBob and Patrick become angry and get into a fight, eventually declaring that they are no longer friends. Squidward comes outside and eats his soufflé while laughing, but in doing so, he chokes on the fork. Patrick saves his life by performing CPR on him (which is basically blowing him up and as the air comes out, the fork can be seen spluttering in between his lips) and becomes Squidward's friend. Inside Squidward's house, Patrick falls asleep while Squidward plays a composition called "Solitude in E Minor" on his clarinet, and Squidward pulls him outside. While doing this, his back cracks and SpongeBob sees this as an opportunity to help him. He bumps into Squidward's back and thus becomes Squidward's friend.
Inside, SpongeBob plays a song (badly) for Squidward on his Double Bass (which he thinks is a bassinet) and when Patrick appears in the window and interrupts the song, SpongeBob destroys the instrument in a fit of rage, and Squidward kicks him out. Squidward then tries to take a bath but Patrick is in the tub. SpongeBob appears in the window and sees this, and he and Patrick begin arguing again, driving Squidward crazy.
Squidward decides to invite Patrick and SpongeBob to a dinner party (without telling either of them that the other is coming) in order to repair their friendship. When they arrive, they are still mad at each other. Squidward tries to get them back together, but the situation devolves into a competition to see who can drink the most soda and thus become Squidward's best friend. Squidward runs out of soda and leaves to get some more. While he is gone, SpongeBob and Patrick, who have become literally inflated from all the soda, begin to hiccup small bubbles that make a burping sound when they burst. They find this amusing and become friends again, but they create so many bubbles that Squidward's house explodes. Squidward orders them out and slams the door. A bubble pops over the door, which then falls over on Squidward, moaning 'Ohhhh! My back...' as the episode ends.
This is the first episode of the series where the "a"s in the crew member's names were not filled in. It has remained this way since. "Plankton!" was the last episode to have filled in "a"s.
Squidward's impression of SpongeBob has a New Jersey accent.
This episode goes to show how gullible SpongeBob and Patrick are, as they fall for Squidward's terrible impressions.
It is revealed that in spite of his low intellect, Patrick can correctly utilize CPR.
This episode reveals what the backside of SpongeBob's, Squidward's and Patrick's houses look like.
When Squidward goes into the bathroom and screams and the scene cuts to Patrick in Squidward's bath, it has become an internet fad called Guess who's in Squidward's bath which has a scary or funny face replacing Patrick's face.
When Squidward uses his keys to unlock the door, there was an explosion. Then Squidward bites his hand and opens the door, already unlocked. The explosion might have broken the lock on the door, though.
When Patrick falls asleep when Squidward plays an E minor, it has an internet fad call Patrick thinks [song, singer or band] is boring where a scene of a song will play and the scene where Patrick is asleep then plays.
SpongeBob said he has been playing a bassinet for years. However, a bassinet is a type of cradle. SpongeBob was actually playing the double bass or a contrabass.
The scene where SpongeBob accidentally spears a picture of Squidward with the bassinet's bow after playing too hard has become an internet fad called SpongeBob attacks his enemy where a funny, or normal face replaces the painting of Squidward.
Squidward could have just told SpongeBob and Patrick the truth about who sent them the mean bubble messages to get them to stop bothering him.
Then again they most likely wouldn't believe him or ignore his explanation.
When Squidward was choking on the fork, it made some people shocked when looking at this.
In Arabic, this episode is called "الجيران المزعجة" which means "Disturbing the Neighbors."
In the Polish dub, the episode's title is "Nieznośni sąsiedzi" meaning "Annoying Neighbors."
In Serbian, this episode's name is "'Najbolji Prijatelji," or "'Best Friends."
In the Croatian dub, the episode name is the same, only that is "Neighbor" instead of "NeighborS."
Some people can get this episode mixed up with the episode "Good Neighbors."
When SpongeBob is playing the "bassinet" (actually a string bass) at Squidward's house, there are only three strings instead of four. However, when SpongeBob smashes the bass, one can see that it now has four strings.
As Patrick and Squidward are walking into Squidward's house, his back window has no glass.
When SpongeBob appears in Squidward's bathroom through his ear window, the window has no glass. In addition, in the next shot, which shows the outside of Squidward's house, SpongeBob is not there, and the ear windows are not even visible.
When SpongeBob and Patrick are stuffed on soda, SpongeBob's holes are missing.
When Squidward returns to his house just as it is destroyed, he has a grocery bag and keys. Afterward, the bag and keys disappear.
If you look closely when SpongeBob is looking at Patrick and Squidward out the window, SpongeBob's eyelashes and holes are missing.
Also, he has five fingers for a shot rather than four.
In the soda scene, if you look closely, at one point Patrick's soda fizz stops moving.
In this episode, Gary's shell is smaller than usual.
Even though the party was deemed a "dinner party," there was no actual food served at the party.
It would be almost impossible for Squidward to make bubbles out of the purple soap off his cake, since he held it and blew it with a pointy fork and the bubbles would probably pop before it gets to SpongeBob or Patrick.
SpongeBob rips his clothes off while launching himself to Squidward, but when he reappears he is wearing his clothes again.
When SpongeBob got kicked out of Squidward's house he was far away from the house, but when the scene changes he was right near his house.
Just before SpongeBob says, "Aha! So this is what I see huh, my best friend and my ex-best friend and rubber bath toys," the sailboat flickers blue for about one second.
When SpongeBob was using bubbles to communicate and when Squidward was tricking them with the fake bubbles the lines on SpongeBob's sock disappear sometimes.