She has light olive-green skin and has light blue hair pulled back into a bun with big pink lips. She wears a navy blue and white uniform, a whistle around her neck, gold colored glasses, and tall brown boots. She and her sisters share a similar appearance.
She wanted Krabby Patties to be banned because they were 'too fun and delicious.' She had her husband close the Krusty Krab and with the help of Plankton, destroyed SpongeBob's home where they were selling Krabby Patties illegally. She then planned to arrest SpongeBob and Mr. Krabs.
T.U.O.O.F.A.T.T.A.F.A.D. is a group dedicated to banning foods it doesn't like, otherwise known as the food police. This may be based on the real-life food police group the Center for Science in the Public Interest, aka the CSPI.
In the credits and TV Guide description, Miss Gristlepuss is mistakenly called Miss Priss.
Despite being married, Miss Gristlepuss is still called "Ms." and "Miss" instead of "Mrs."