Los Angeles is the largest city in the state of California and the second largest in the United States. Often abbreviated as L.A. and nicknamed The City of Angels, Los Angeles has an estimated population of 3,976,322 and spans over 498.3 square miles (1,290.6 km2) in Southern California.
- Los Angeles is the city in which the neighborhood, Encino, the home of Patchy, Potty, and Mrs. Johnson, is located.
- Los Angeles is also the city that Mr. Pirateson and the Gorilla live in. This city is the place where The Poop Deck and Don's Import Store & Delicatessen are located.
- Nickelodeon Animation Studio is located in Burbank, which is part of the Greater Los Angeles Area, although not within the actual city limits of Los Angeles, as Burbank split from the city of Los Angeles in 1911.