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In "Perfect Chemistry," the two meet and Sandy calls Karen beautiful. Karen is very happy about the compliment.
In "Salsa Imbecilicus," Karen and Sandy are the only residents of Bikini Bottom who are not turned into idiots by the stream from Plankton's sauce. They work together to create a university, which eventually returns everyone else to their normal intelligence. This episode reveals that Karen knows where Sandy lives and that her home is called a treedome, implying that she has visited Sandy.
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