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Karen's relationship with Sandy is a purely positive one. They are both level-headed and intelligent characters with an appreciation for inventions, which is why they have had friendly interactions throughout the series.

In "Perfect Chemistry," the two meet and Sandy calls Karen beautiful. Karen is very happy about the compliment.

In "Frozen Face-Off," Sandy and her friends save Karen from being frozen. Later, Sandy uses Karen's body to save Squidward, who has been frozen in a block of ice.

In "Salsa Imbecilicus," Karen and Sandy are the only residents of Bikini Bottom who are not turned into idiots by the stream from Plankton's sauce. They work together to create a university, which eventually returns everyone else to their normal intelligence. This episode reveals that Karen knows where Sandy lives and that her home is called a treedome, implying that she has visited Sandy.

Sleepy Time 052
I can turn into a skyscraper!
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