The episode begins with Squidward trying to decide which nose he should get because he is going to get a nose job. While caught up in himself, Squidward is interrupted by SpongeBob on his unicycle. Reluctantly, Squidward allows SpongeBob to come with him. SpongeBob lets Squidward ride with him to the hospital.
Squidward goes into his hospital room with SpongeBob closely following. SpongeBob realizes how drab the room is and brightens it up with plushes and flowers. Irritated, Squidward yells at SpongeBob and tells him to go volunteer to be a candy striper. SpongeBob grabs his uniform and eats the literal candy strings on it. A couple of doctors passing by see SpongeBob in his stripeless white shirt and mistake him for a doctor and tell him to come along and help them. They bring SpongeBob into a room with a catfish. The catfish tells them in a gravelly voice that his throat hurts. SpongeBob reaches into the fish's neckfold and finds a clump of dirt. He then reaches into the catfish's mouth and pulls out some car keys. SpongeBob then explains how the fish is a bottom feeder and how they probably ate the keys in a search for food, stating that this also happens to his best friend, Patrick, all the time.
SpongeBob is then moved into another room with an athlete with broken legs. The athelete asks if he will be able to run in an upcoming marathon. One doctor begins to say "no," but SpongeBob insists he can fix it. He grabs a nearby skeleton model and shoves it inside of the patient. The patient's legs are healed and he runs out of his room. The two doctors are amazed! As a result they bring SpongeBob into the final room.
The room contains deflated Mrs. Puff inside of an Iron Lung. SpongeBob mistakes the Lung for a submarine and hops on top of it. He starts pushing and pressing levers and buttons and the Lung streaks down the hallway. It crashes into the end and shoots out a puffed up Puff. She thanks him for helping her recover, but says he still won't get a drivers license.
The doctors are befuddled and allow SpongeBob to perform a surgery. The surgery patient ends up being Squidward. SpongeBob tries several differnet noses but Squidward doesn't like any of them. SpongeBob then reverts his nose back to normal, but says he needed the rest of his body to make it, much to Squidward's horror. SpongeBob now has to leave for work, but the doctors tell him that he already is. However, SpongeBob tells them that his actual job is a fry cook and then proceeds to leave and walk to the Krusty Krab. Squidward then says to the female nurses that he's on the market and single, much to their disgust and shock.
This episode may take place after "Demolition Doofus" because Mrs. Puff is in the hospital being treated from having puffing problems.
This episode may also take place after "Mrs. Puff, You're Fired" because SpongeBob cannot drive the puffing machine well with eyes open but can drive well when wearing safety goggles.
When SpongeBob comments "Mmm, strawberry!" after eating the candy stripes on his doctor uniform, this is a reference to when he makes the same comment after eating the red lines Squidward draws on the screen in "Lost in Bikini Bottom."
This is the second episode in which the lung machine is shown. The first is "Funny Pants."
This is the first appearance of Squilliam Fancyson since "Back to the Past," though only his face briefly appears as part of one of Squidward's noses during the nose job montage.
The "My leg!" gag is referenced in this episode when the Iron Lung crashes into an Athlete Fish and he screams "My legs!"
When SpongeBob has to leave the hospital for work, he says "D'oh" at first. This may be a reference to Homer Simpson's catchphrase from The Simpsons.
When the Athlete Fish runs with his legs backwards, it's a reference to Mr. Muddle from Mr. Men and Little Miss when he manages to have his legs walk one way and him going another way.
The way Squidward is wrapped up after surgery at the end is a reference to the 1977 movie Eraserhead.
When SpongeBob is saying he used Squidward's limbs to sculpt his new nose, the outline of Squidward's feet are still under the covers, which contradicts what SpongeBob is saying about the limbs, as Squidward still has his feet in the shot.