|First appearance:||Patty Hype|
|Latest appearance:||Goo Goo Gas|
|List of species|
Amoebas are microscopic one-celled organisms that were first shown in the episode Patty Hype when Mr. Krabs wasn't receiving business in the Krusty Krab and was watching a show about them. They also appeared when SpongeBob turned Plankton into a baby (as seen in the episode Goo Goo Gas). He was shrunken down after being hit by the Goo Goo Gas to microscopic smallness. The Amoebas were shown to say that Plankton's baby size is microscopic.
Amoebas are featured in the mini-games of SpongeBob's Atlantis SquarePantis.