Everybody got invitations from SpongeBob. They go to his house to be surprised that they are going to see vacation slides (which they don't care about). The adventure starts with Patrick squirting liquid cheese fizz on the camera. SpongeBob's parents pull up and get SpongeBob and Patrick in. SpongeBob looks at a brochure and Patrick suggests a game- Hide and Seek. Patrick gets on the windshield of the car and Harold yells "Egad!!!"' and looses control. They slide and burst into The Outskirts Outlet Mega-Mall, and Basscar Racing Stadium. Then they fling off the stadium and heads straight into space where a floating cow gets hit by them and lands on the moon. Then they fall back down to the Earth and slide down a rocky cliff onto the road. SpongeBob then suggests they sing a road song.
Everyone sings the road song and at the end of the song the engine blows up. They move the car to a local service station. They wait in an outhouse. Margret sees a playground and offers SpongeBob and Patrick to play on it. They do, but they slide down a sewer pipe and onto a small puddle.
When they get up, they try to get back up, but they can't. They enter a mysterious red kelp forest with many mushrooms. They hear a hollering noise and run. It turns out its a small creature. They jump over a cliff and onto an anemone and onto a mushroom. Behind Patrick is a giant fruit fly. They run away and behind a rock. They hear a noise. It came from a gift shop. SpongeBob wastes his money on useless knick-knacks. They sing the road song wearily. Then SpongeBob decides to play the road song on a flute he bought at the gift shop. They walk along past Harold and Margret and into the forest again. Animals follow them. The animals suddenly run away because the giant fruit fly is behind them. SpongeBob stops playing. When they turn around they see the fruit fly wants to give them a lift. They then sing the above the road song. He drops SpongeBob and Patrick off. SpongeBob's parents call them over but SpongeBob and Patrick just fell asleep. Margaret says "Do something Harold!" while Harold says "He's your son, Margaret, he's your son..."
Patrick getting the cheese-fizz in his eye was similar to how SpongeBob got chum in his eyes in Chum Caverns.
SpongeBob playing the flute and causing weird animals to follow him may be a reference to the 'Pied Piper of Hamelin'. This is the second episode where Patrick is mistaken as luggage. The first was in "The Great Patty Caper."
This is the second time Baytona is mentioned. The first is The Hot Shot.
The episode was promoted as "Runaway Roadtrip" in Ireland and the UK but the actual episode is still called "A Squarepants Family Vacation".
SpongeBob's mother's first name is revealed to be Margaret.
This is the only double-length vacation episode.
This is the second episode to be a long flashback sequence, first was Missing Identity. Unlike that episode, this doesn't bring us back to the actual setting, making the whole flashback the rest of the episode. This goes the same for the rest of the vacation miniseries.