SpongeBob and Patrick are upset, because Sandy has gone to Texas for 2 days, they decide to throw her a welcome home party. During their party, SpongeBob and Patrick notice that Sandy is scratching and biting her fur. Sandy explains that upon her return from a science convention in Texas, she unknowingly brings back a flea. Sandy asks SpongeBob to open her briefcase and take out the flea collar. The flea jumps out of her fur and lands on SpongeBob. SpongeBob gets bitten and grabs the collar. The flea then lands on Patrick and bites him, causing Patrick to take the collar. They fight over the collar, then Sandy grabs the collar and wraps it around all three of them. The flea then reproduces, causing the flea collar to be eaten away, rending it useless. Fleas take over Sandy's treedome, and no one can escape the dome. Patrick blames SpongeBob for throwing the party and getting infected, then blames Sandy for bringing the flea. SpongeBob states they may be living in a sea of fleas instead of salt water, thus giving Sandy an idea on how to get rid of the fleas. Sandy was unique crashing into the cauldron with fleas by infecting all their space in the dome with saltwater, but all the Bikini Bottom citizens are stuck in the dome at the end.
When Patrick regurgitates Sandy's cake, it is in the shape of Texas.
The bus driver who hates SpongeBob's singing is Nat Peterson.
This episode possibly takes place before the episode "Squirrel Jokes," because in this episode SpongeBob doesn't know what fleas are. In Squirrel Jokes, he makes fun about how squirrels have many fleas.
Squidward was doing a power walk and said "Heel, toe, heel, toe" just like in "Bucket Sweet Bucket."
This was the second episode we see Sandy Cheeks without her helmet and wearing her suit inside her treedome.